Cholera Vaccines

Cholera vaccines.

Cholera causes significant morbidity and mortality worldwide. For travelers, the risk of developing cholera per month of stay in a developing country is approximately 0.001%-0.01%, and cholera may present as traveler's diarrhea. In the United States, only a poorly tolerated, marginally effective, parenterally administered, phenol-inactivated vaccine is available. Outside the United States, 2 ad...

What about cholera vaccines?

Claire-Lise Chaignat Global Task Force on Cholera Control, Department of Neglected Tropical Diseases, Communicable Diseases Cluster, World Health Organization, 20, av. Appia, 1211 Geneva 27, Switzerland Tel.: +41 227 913 914 Fax: +41 227 914 777 [email protected] “...cholera is re-emerging, in conjunction with the ever-increasing proportion of vulnerable populations living in unsanitary conditi...

Oral vaccines against cholera.

The current seventh pandemic of cholera, caused by serogroup O1, El Tor biotype, has now involved almost the entire developing world. The ongoing dynamic epidemiology of cholera, involving evolution of new strains, prolonged and more frequent epidemics, increased antimicrobial resistance, and awareness of the role of climate change upon the global burden has returned cholera to the forefront of...

Technical considerations of cholera vaccines and some results of cholera - El-Tor mass immunization

Present status of cholera vaccines.

crease in enterotoxin production. Based on their findings, toxin-enriched culture filtrates for separation studies have been produced by the Centre for Applied Microbiology and Research, Porton Down, in collaboration with this laboratory, using a 20 litre batch fermentation technique with controlled pH 7.5, aeration of 10 litres/min, agitation at 500rev./min and incubation at 36°C for 5-6h. Cel...